PUBLICATIONS

2024

Zhu H, You Y, Yu B, Deng Z, Liu M, Hu Z, Duan J. Loss of the ceramide synthase HYL-2 from Caenorhabditis elegans impairs stress responses and alters sphingolipid composition. J Biol Chem. 2024 Jun;300(6):107320. 

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Liu M, You Y, Zhu H, Chen Y, Hu Z, Duan J. N-Acetylcysteine Alleviates Impaired Muscular Function Resulting from Sphingosine Phosphate Lyase Functional Deficiency-Induced Sphingoid Base and Ceramide Accumulation in Caenorhabditis elegans. Nutrients. 2024 May 26;16(11):1623.

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2023

Hu Z, Duan J. 1-Deoxysphingolipids and Their Analogs in Foods: The Occurrence and Potential Impact on Human Health. J Nutr Sci Vitaminol (Tokyo). 2022;68(Supplement):S146-S148.

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2022

Hu, Z.;  Chen, Y.;  Wang, X.;  Deng, Y.;  Wang, X.;  Li, S.;  Ding, X.; Duan, J., Accumulation of Fatty Acylated Fusarium Toxin 2-Amino-14,16-dimethyloctadecan-3-ol, a Class of Novel 1-Deoxysphingolipid Analogues, during Food Storage. J Agric Food Chem 2022, 70 (16), 5151-5158.

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2021

Ding, R., L. Liu, Z. Hu, A. Wu, H. Zhu, Q. Ruan, H. Qiu, Y. Hong, B. Hu and J. Duan (2021). "In vivo noninvasive and rapid evaluation of pearls in freshwater mussels based on micro-CT." Aquaculture 534: 736232.

 

2020

Liu, R., Lu, X.-L., Huang, X.-H., He, W., Duan, J.-J., Zhang, J., & Li, J. (2020). Complex structure of human Hsp90N and a novel small inhibitor FS5. Nuclear Science and Techniques, 31(3).

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2019

Melum E, Jiang X, Baker KD, Macedo MF, Fritsch J, Dowds CM, Wang J, Pharo A, Kaser A, Tan C, Pereira CS, Kelly SL, Duan J, Karlsen TH, Exley MA, Schuetze S, Zajonc DM, Merrill AH, Schuchman EH, Zeissig S, Blumberg RS. Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin. Nature Immunology 2019, 20(12): 1644.

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Wan, J., Li, J., Bandyopadhyay, S., Kelly, S. L., Xiang, Y., Zhang, J., Merrill, A. H., Jr., Duan, J., Analysis of 1-Deoxysphingoid Bases and Their N-Acyl Metabolites and Exploration of Their Occurrence in Some Food Materials. J Agric Food Chem 2019, 67 (46), 12953-12961. 

 

Duan, J., Li, J., Chen, G. L., Ge, Y., Liu, J., Xie, K., Peng, X., Zhou, W., Zhong, J., Zhang, Y., Xu, J., Xue, C., Liang, B., Zhu, L., Liu, W., Zhang, C., Tian, X. L., Wang, J., Clapham, D. E., Zeng, B., Li, Z., Zhang, J., Cryo-EM structure of TRPC5 at 2.8-A resolution reveals unique and conserved structural elements essential for channel function. Sci Adv 2019, 5 (7), eaaw7935.

 

Watanabe, M., Zhang, J., Mansuri, M. S., Duan, J., Karimy, J. K., Delpire, E., Alper, S. L., Lifton, R. P., Fukuda, A., Kahle, K. T., Developmentally regulated KCC2 phosphorylation is essential for dynamic GABA-mediated inhibition and survival. Sci Signal 2019, 12 (603).

 

Pisella, L. I., Gaiarsa, J. L., Diabira, D., Zhang, J. W., Khalilov, I., Duan, J., Kahle, K. T., Medina, I., Impaired regulation of KCC2 phosphorylation leads to neuronal network dysfunction and neurodevelopmental pathology. Sci Signal 2019, 12 (603).

 

Melum, E., Jiang, X., Baker, K. D., Macedo, M. F., Fritsch, J., Dowds, C. M., Wang, J., Pharo, A., Kaser, A., Tan, C., Pereira, C. S., Kelly, S. L., Duan, J., Karlsen, T. H., Exley, M. A., Schutze, S., Zajonc, D. M., Merrill, A. H., Schuchman, E. H., Zeissig, S., Blumberg, R. S., Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin. Nat Immunol 2019. Dec,20(12):1644-1655.

 

Sugawara, T., Aida, K., Duan, J., Tomonaga, N., Manabe, Y., Hirata, T., Analysis of Chemical Structures of Glucosylceramides from Rice and Other Foodstuffs. J Nutr Sci Vitaminol (Tokyo) 2019, 65 (Supplement), S228-S230.

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2018

Duan, J., Li, Z., Li, J., Santa-Cruz, A., Sanchez-Martinez, S., Zhang, J. and Clapham D.E.. (2018) Structure of full-length human TRPM4. Proc Natl Acad Sci U S A 115 (10), 2377-2382.

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​Duan, J., Zeng, B., Chen, GL, Peng, X., Zhang, Y., Wang, J., Clapham D.E., Li, Z. and Zhang, J.,  (2018)  Structure of the mouse TRPC4 ion channel. Nature Communications  9 (1), 3102.

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​Duan, J., Li, Z., Li, J., Hulse RE, Santa-Cruz, A., Valinsky, C., Abiria, S., Krapivinsky G.，Zhang, J.  and  Clapham D.E.. (2018) Structure of the mammalian TRPM7, a magnesium channel required during embryonic development. Proc Natl Acad Sci U S A 115(35), 8201-8210.

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​Liu, X., Vien, T., Duan, J., Sheu, S., DeCaen, P. G. and Clapham, D. E. (2018) Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium. Elife  7, e33183.

 

2017

Volpert, G., Ben-Dor, S., Tarcic, O., Duan, J., Saada, A., Merrill, A.H. Jr, Pewzner-Jung, Y., Futerman, A. H. (2017). Oxidative stress elicited by modifying the ceramide acyl chain length reduces the rate of clathrin-mediated endocytosis. J Cell Sci 130, 1486-1943.

 

2016

Duan, J., Ishida, M., Aida, K., Tsuduki, T., Zhang, J., Manabe, Y., Hirata, T. and Sugawara, T. (2016) Dietary Cerebroside from Sea Cucumber (Stichopus japonicus): Absorption and Effects on Skin Barrier and Cecal Short-Chain Fatty Acids. J Agric Food Chem 64, 7014–7021.

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Davoli, T., Mengwasser, K.E., Duan, J., Chen, T., Christensen, C., Wooten, E.C., Anselmo, N.A., Li, Z.M., Wong, K., Kahle K., Elledge, S. (2016).  Functional genomics reveals that tumors with activating phosphoinositide 3-kinase mutations are dependent on accelerated protein turnover. Genes & Development 30 (24), 2684-2695.

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Klein, A.D., Ferreira, N.S., Ben-Dor, S., Duan, J., J Hardy, TM Cox, Merrill, A.H. and Futerman, A.H. (2016) Identification of Modifier Genes in a Mouse Model of Gaucher Disease. Cell Reports 16, 2546-2553.

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Kahle K., Khanna A.R., Duan, J., Staley, J. K., Delpire, E., and Poduri, A. (2016). The KCC2 cotransporter and human epilepsy: getting excited about inhibition. Neuroscientist 22 (6), 555-562.

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2015

Duan, J. and Merrill, A.H. (2015) 1-Deoxysphingolipids encountered exogenously and made de novo: dangerous mysteries inside an enigma. J Biol Chem. 290, 15380-15389.

 

Gorden, D. L., Myers, D. S., Ivanova, P. T., Fahy, E., Maurya, M. R., Gupta, S., Min, J., Spann, N. J., McDonald, J. G., Kelly, S. L., Duan, J., Sullards, M. C., Leiker, T. J., Barkley, R. M., Quehenberger, O., Armando, A. M., Milne, S. B., Mathews, T. P., Armstrong, M. D., Li, C., Melvin, W. V., Clements, R. H., Washington, M. K., Mendonsa, A. M., Witztum, J. L., Guan, Z., Glass, C. K., Murphy, R. C., Dennis, E. A., Merrill, A. H., Jr., Russell, D. W., Subramaniam, S. and Brown, H. A (2015). Biomarkers of NAFLD progression: a lipidomics approach to an epidemic. J Lipid Res 56, 722-736.

 

Friedel P., Kahle T. K., Zhang J., Hertz N., Pisella I. L., Buhler E., Schaller F., Duan J., Khanna A.R., Bishop N. P., Shokat M. K., and Medina I. (2015) WNK1-regulated inhibitory phosphorylation of KCC2 maintains depolarizing GABA activity in immature neurons. Sci Signal 8 (383).

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Before 2014

Kahle K., Schmouth J.F., Lavastre V., Latrémolière A., Zhang J., Andrews N., Omura T., Laganière J., Rochefort D., Hince P., Castonguay G., Gaudet R., Mapplebeck J., Sotocinal S., Duan J., Ward C., Khanna A., Mogil J., Dion P., Woolf C.J., Inquimbert P. and Rouleau G.A. (2016) Inhibition of the  kinase  WNK1/HSN2  ameliorates neuropathic pain by restoring GABA inhibition. Sci Signal 9 (421).

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Farfel-Becker, T., Vitner, E.B., Kelly, S.L., Bame, J.R., Duan, J., Shinder, V., Merrill, A.H., Jr., Dobrenis, K., and Futerman, A.H. (2014). Neuronal accumulation of glucosylceramide in a mouse model of neuronopathic Gaucher disease leads to neurodegeneration. Hum Mol Genet 23, 843-854.

 

Jimenez-Rojo, N., Sot, J., Busto, J.V., Shaw, W.A., Duan, J., Merrill, A.H., Jr., Alonso, A., and Goni, F.M. (2014). Biophysical properties of novel 1-deoxy-(dihydro)ceramides occurring in mammalian cells. Biophys J 107, 2850-2859.

Duan, J., Sugawara, T., Hirose, M., Aida, K., Sakai, S., Fujii, A., and Hirata, T. (2012). Dietary sphingolipids improve skin barrier functions via the upregulation of ceramide synthases in the epidermis. Exp Dermatol 21, 448-452.

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Duan, J., Sugawara, T., Hirose, M., Aida, K., Sakai, S., Fujii, A., and Hirata, T. (2012). Dietary sphingolipids improve skin barrier functions via the upregulation of ceramide synthases in the epidermis. Exp Dermatol 21, 448-452.

 

Duan, J., Sugawara, T., Sakai, S., Aida, K., and Hirata, T. (2011).  Oral glucosylceramide reduces 2,4-dinitrofluorobenzene induced inflammatory response in mice by reducing TNF-alpha levels and leukocyte infiltration. Lipids 46, 505-512.

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Duan, J., Sugawara, T., and Hirata, T. (2010). Rapid quantitative analysis of sphingolipids in seafood using HPLC with evaporative light-scattering detection: its application in tissue distribution of sphingolipids in fish. J Oleo Sci 59, 509-513.​​​

 

Kitano, Y., Murazumi, K., Duan, J., Kurose, K., Kobayashi, S., Sugawara, T., and Hirata, T. (2012). Effect of dietary porphyran from the red alga, Porphyra yezoensis, on glucose metabolism in diabetic KK-Ay mice. J Nutr Sci Vitaminol (Tokyo) 58, 14-19.

 

​Xu, J., Duan, J., Xue, C., Feng, T., Dong, P., Sugawara, T., and Hirata, T. (2011). Analysis and comparison of glucocerebroside species from three edible sea cucumbers using liquid chromatography-ion trap-time-of-flight mass spectrometry. J Agric Food Chem 59, 12246-53.

 

Sugawara, T., Duan, J., Aida, K., Tsuduki, T., and Hirata, T. (2010). Identification of glucosylceramides containing sphingatrienine in maize and rice using ion trap mass spectrometry. Lipids 45, 451-455.

 

Sugawara, T., Tsuduki, T., Yano, S., Hirose, M., Duan, J., Aida, K., Ikeda, I., and Hirata, T. (2010). Intestinal absorption of dietary maize glucosylceramide in lymphatic duct cannulated rats. J Lipid Res 51, 1761-1769.

 

Sugawara, T., Aida, K., Duan, J., and Hirata, T. (2010). Analysis of glucosylceramides from various sources by liquid chromatography-ion trap mass spectrometry. J Oleo Sci 59, 387-394.

 

Yamasaki, Y., Katsuo, D., Nakayasu, S., Salati, C., Duan, J., Zou, Y., Matsuyama, Y., Yamaguchi, K., and Oda, T. (2008). Purification and characterization of a novel high molecular weight exotoxin produced by red tide phytoplankton, Alexandrium tamarense. J Biochem Mol Toxicol 22, 405-415.